CNS Depression: The most commonly encountered adverse effects are mild sedation, dysphoria and ataxia. Somnolence, ptyalism and nausea are also possible.
Gastrointestinal Signs: Gastrointestinal irritation is occasionally reported.
Species-Specific Adverse Effects: No species-specific adverse effects have been identified.

Hypersensitivity: Avoid use in animals with known hypersensitivity to the drug or its ingredients.
Behavioural Issues: Gabapentin should be used with caution in patients with behavioural disturbances.
Renal Disease: Use with caution or reduce the dose if renal function is significantly impaired (IRIS stage 2+).

Pregnancy: Avoid Use; Evidence of fetotoxicity in Rodents and Rabbits (Fetal loss or delayed ossification of bones in the skull, vertebrae, forelimb and hind limbs)
Lactation: Avoid Use; Gabapentin distributes into milk following oral administration.
Fertility: Avoid Use. Fertility rate and other parameters concerned with fertility, sex hormones and specific biochemical profiles were significantly disturbed in male rats (Daoud et al., 2004).

Antacids: Absorption is reduced when concurrent antacids are used. Especially those containing aluminium with magnesium. Some authors recommend that Gabapentin is taken at least 2 hours after the administration of any Antacid.

Cimetidine: May reduce Gabapentin clearance
Ketamine: Ketamine and Gabapentin may work synergistically to provide analgesia
Morphine: May increase Gabapentin levels
Tramadol: Tramadol and Gabapentin may work synergistically to provide analgesia.

Prevalence: Reported toxicity is rare within clinical settings. Gabapentin appears clinically safe in cats, dogs and rabbits when used following the advised dosage protocols.
Expected Signs: Sedation, akinesia and ataxia, lack of muscle coordination, tremors, ptyalism, diarrhoea and vomiting, lethargy, irregular or laboured breathing, loss of consciousness.
Mechanism: Excessive CNS depression at the various sites of gabapentin action within the brain.
Species Specific Information: Limited; No data located
Clinical Response: Active decontamination. Response to a significant oral overdose may include emesis, activated charcoal, cathartics and intravenous fluids to accelerate elimination.
Antidotes: None identified
Reversal Agents: Gabapentin appears devoid of any reversal agent. Alpha-adrenergic pressor agents (e.g., norepinephrine, phenylephrine, not epinephrine) can be considered in severe hypotension.
Co-administered Agents: Consider Reversal. Avoid reversal of analgesia agents and anaesthetics unless provision is made to support any critical patient.